Our program is broadly based on modern synthetic chemistry. We are developing synthetic tools (reactions and reagents) and networks of reactions (synthetic strategies) for efficient and selective chemical synthesis. In particular, we focus on the development of chemical transformations that can resolve longstanding synthetic problems and offer new mechanistic vistas for future development in organic synthesis. Our investigations are also concerned with the synthesis of natural products with complex molecular architecture and significant biological activities. Our goal is to establish synthetic roadmaps to the target molecules, to evolve new synthesis logics, and to uncover the molecular bases for the peculiar properties of these compounds. New Reaction Development The research in this area involves discovering, understanding, and exploiting new catalyst systems that effect bond formation with control of chemo-, regio- and stereoselectivities. Our approach is to identify novel reactivities and mechanistic motifs of transition metal-mediated processes to develop conceptually new reactions of broad synthetic utility. Specific topics include the development of stereoselective carbon-heteroatom bond-forming reactions for the asymmetric synthesis of chiral ethers and amines, and new cyclization reactions through catalytic carbon-carbon bond formation. Synthesis of Natural Products Target molecules in our lab include a variety of natural products possessing interesting structural, biological, and physical properties. In each project, we probe the feasibility of unprecedented reactions or untested networks of reactions in complex structural and functional settings. By undertaking these chemical synthesis investigations, we aim to develop innovative new chemistry that will be of great utility in broader contexts. Thus, our endeavor will not only advance synthetic science but also foster opportunities for further explorations utilizing these molecular agents.